{\rtf1\ansi\ansicpg1252\cocoartf1187\cocoasubrtf340 {\fonttbl\f0\fswiss\fcharset0 Helvetica;\f1\fnil\fcharset0 LucidaGrande;\f2\fswiss\fcharset0 ArialMT; \f3\fnil\fcharset0 Verdana;\f4\froman\fcharset0 Times-Roman;\f5\fnil\fcharset136 STHeitiTC-Light; } {\colortbl;\red255\green255\blue255;\red26\green26\blue26;\red255\green255\blue255;\red14\green14\blue14; \red109\green109\blue109;} \margl1440\margr1440\vieww10800\viewh8400\viewkind0 \pard\tx720\tx1440\tx2160\tx2880\tx3600\tx4320\tx5040\tx5760\tx6480\tx7200\tx7920\tx8640\pardirnatural \f0\fs24 \cf0 ============ \ Description: \ ============ \ \ This is the main function to \f1\fs28 \cf2 \cb3 obtain nonlinear, data-adaptive dynamic equations from the observed longitudinal processes. The dynamic equation is numerically estimated via smoothing-based procedure on the pre-smoothed trajectories and derivatives \f0\fs24 \cf0 \cb1 . \ dimensional data is implemented with distance-based metric Multidimensional Scaling, \ mapping high-dimensional data to locations on a real interval, such that predictors that \ are close in a suitable sample metric also are located close to each other on the interval. \ Established techniques from Functional Data Analysis can \ be applied for further statistical analysis once an underlying stochastic process and the \ corresponding random trajectory for each subject have been identified. \ \ Reference: \f2\fs26 \cf2 \cb3 Nicolas Verzelen,\'a0 Wenwen Tao,\'a0 and\'a0Hans-Georg M\'fcller\ \pard\pardeftab720\sl280 \f3\fs22 \cf4 Inferring stochastic dynamics from functional data\ \pard\pardeftab720 \f4\fs24 \cf5 Biometrika \f3\fs18 \'a0 \f4\fs24 (2012)\'a099(3):\'a0533-550\'a0first published online\'a0July 9, 2012\'a0doi:10.1093/biomet/ass015 \f3\fs22 \cf4 \ \pard\tx720\tx1440\tx2160\tx2880\tx3600\tx4320\tx5040\tx5760\tx6480\tx7200\tx7920\tx8640\pardirnatural \f0\fs24 \cf0 \cb1 \ \ ======== \ Usage: \ ======== \ \ [mu,dyn_grid]=non_dyn(t,y,method,tout,N_f)\ \ \ \pard\tx720\tx1440\tx2160\tx2880\tx3600\tx4320\tx5040\tx5760\tx6480\tx7200\tx7920\tx8640\pardirnatural \cf0 =======\ Input:\ =======\ \pard\tx720\tx1440\tx2160\tx2880\tx3600\tx4320\tx5040\tx5760\tx6480\tx7200\tx7920\tx8640\pardirnatural \cf0 t :1 * N cell of observed time points. Need to be coherent for all subjects\ y :1 * N cell of observed repeated measurements for each subject, corresponding to each cell of t.\ method :a character string for the kernel to be used, default is 'gauss' \f5 ; should be specified as one of the following \f0 \ 'epan' - epanechikov kernel\ 'gauss' - gaussian kernel\ 'gausvar' - variant of gaussian kernel\ 'rect' - rectangular kernel\ 'quar' - quartic kernel\ tout : m * 1 vector of the output time grid ; default is equadistance 1*100 grid between min(t\{1\}) and max(t\{1\}). \ N_f :scalar that gives the output size of trajectory y grid; default is 200.\ \ \ \ Details: i) Any unspecified or optional arguments can be set to "[]" for \ default values;\ \ ======= \ Output: \ =======\ \ \ \pard\tx720\tx1440\tx2160\tx2880\tx3600\tx4320\tx5040\tx5760\tx6480\tx7200\tx7920\tx8640\pardirnatural \cf0 mu :m * N_f matrix of the estimated dynamic surface on given time grid and trajectory grid (N_f equidistant grid on the support region)\ dyn_grid :m * N_f matrix of the output grid corresponding to mu. \ \pard\tx720\tx1440\tx2160\tx2880\tx3600\tx4320\tx5040\tx5760\tx6480\tx7200\tx7920\tx8640\pardirnatural \cf0 \ \ \ See example_non_dyn.m \ }